Human Papillomavirus (HPV) type 16/18 E7 proteins
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Human Papillomavirus (HPV) type 16/18 E7 proteins
Human papillomavirus (HPV) types 16 and 18 are frequently associated with human cervical cancer. The E7 protein has a critical function in cell tumor transformation. The HPV16/18 E7 proteins are composed of approximately 100 amino acids and are divided into three conserved regions, CR1, CR2, and CR3. A small portion of CR1 and nearly entire CR2 has sequence similarity with adenovirus (Ad) E1A proteins and large T antigen of SV40. The CR3 region encodes a zinc finger domain containing two CXXC motifs, and is responsible for zinc-dependent dimerization. It mediates E7 interaction with p21 and pRB, cellular proteins responsible for cell cycle regulation and apoptosis.
Human Papillomavirus type 16 E7 protein (HPV16E7)
Description: HPV16E7 protein, Cat. #2702, is highly purified full-length (98aa) HPV16E7 protein, expressed in E. coli. The purified protein has an N-term 6x his-tag. This product is useful for ELISA screening and other assays. Please see the 2702 and 2702/S datasheets for additional information.
Supplied as: 100µg HPV16 E7 protein lyophilized or 0.5mg in solution (1mg/mL)
Price:
Cat. #2702 (lyophilized) 100µg/$200; 5 x 5µg/$800 (shipped on blue ice or RT)
Cat. #2702/S (1mg/mL) 0.5mg/$800; 5 x 0.5mg/$3200 (shipped on dry ice)
Please contact us for custom packaging and larger quantities.
Original Reference:
This product was developed at Tulip Biolabs, Inc.
Useful References:
Bello-Rios C, et al. (2021) Int. J. Mol. Sci. 22 1400; doi.org/10.3390/ijms22031400


Human Papillomavirus type 18 E7 protein (HPV18E7)
Description: HPV18E7 protein, Cat. #2704, is highly purified full-length (105aa) HPV18E7 protein, expressed in E. coli. The purified protein has an N-term 6x his-tag. This product is useful for ELISA screening and other assays. Please see the 2704 and 2704/S datasheets for additional information.
Supplied as: 100µg HPV18 E7 protein lyophilized or 0.5mg in solution (1mg/mL)
Price:
Cat. #2704 (lyophilized) 100µg/$200; 5 x 5µg/$800 (shipped on blue ice or RT)
Cat. #2704/S (1mg/mL) 0.5mg/$800; 5 x 0.5mg/$3200 (shipped on dry ice)
Please contact us for custom packaging and larger quantities.
Original Reference:
This product was developed at Tulip Biolabs, Inc.
Useful References:
Bello-Rios C, et al. (2021) Int. J. Mol. Sci. 22 1400; doi.org/10.3390/ijms22031400

Please contact us for custom manufacturing, packaging, bulk quantities, special conjugations, and more. Your inquiries are always confidential.