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Human Papillomavirus (HPV) type 16/18 E7 proteins

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Human Papillomavirus (HPV) type 16/18 E7 proteins

Human papillomavirus (HPV) types 16 and 18 are frequently associated with human cervical cancer. The E7 protein has a critical function in cell tumor transformation.  The HPV16/18 E7 proteins are composed of approximately 100 amino acids and are divided into three conserved regions, CR1, CR2, and CR3.  A small portion of CR1 and nearly entire CR2 has sequence similarity with adenovirus (Ad) E1A proteins and large T antigen of SV40.  The CR3 region encodes a zinc finger domain containing two CXXC motifs, and is responsible for zinc-dependent dimerization.  It mediates E7 interaction with p21 and pRB, cellular proteins responsible for cell cycle regulation and apoptosis.

Human Papillomavirus type 16 E7 protein (HPV16E7)

Description: HPV16E7 protein, Cat. #2702, is highly purified full-length (98aa) HPV16E7 protein, expressed in E. coli.  The purified protein has an N-term 6x his-tag. This product is useful for ELISA screening and other assays.  Please see the 2702 and 2702/S datasheets for additional information.


Supplied as: 100µg HPV16 E7 protein lyophilized or 0.5mg in solution (1mg/mL)


Price:

Cat. #2702 (lyophilized) 100µg/$200; 5 x 5µg/$800 (shipped on blue ice or RT)

Cat. #2702/S (1mg/mL) 0.5mg/$800; 5 x 0.5mg/$3200 (shipped on dry ice)

Please contact us for custom packaging and larger quantities.


Original Reference:

This product was developed at Tulip Biolabs, Inc.


Useful References:

Bello-Rios C, et al. (2021) Int. J. Mol. Sci. 22 1400; doi.org/10.3390/ijms22031400




#2702 HPV16E7


#2702/S HPV16E7


Human Papillomavirus type 18 E7 protein (HPV18E7)

Description: HPV18E7 protein, Cat. #2704, is highly purified full-length (105aa) HPV18E7 protein, expressed in E. coli.  The purified protein has an N-term 6x his-tag.  This product is useful for ELISA screening and other assays. Please see the 2704 and 2704/S datasheets for additional information.


Supplied as: 100µg HPV18 E7 protein lyophilized or 0.5mg in solution (1mg/mL)


Price:

Cat. #2704 (lyophilized) 100µg/$200; 5 x 5µg/$800 (shipped on blue ice or RT)

Cat. #2704/S (1mg/mL) 0.5mg/$800; 5 x 0.5mg/$3200 (shipped on dry ice)

Please contact us for custom packaging and larger quantities.


Original Reference:

This product was developed at Tulip Biolabs, Inc.


Useful References:

Bello-Rios C, et al. (2021) Int. J. Mol. Sci. 22 1400; doi.org/10.3390/ijms22031400


#2704 HPV18E7


#2704/S HPV18E7


Please contact us for custom manufacturing, packaging, bulk quantities, special conjugations, and more.  Your inquiries are always confidential.